Recombinant Human TGF-beta 1 Protein (This is also the reason too much Vitamin A is toxic. We have been able to assemble more than 6000 recombinant proteins, peptides and antibodies which are crucial to the research community. The hedgehog system in ovarian follicles of cattle selected for twin ovulations and births: evidence of a link between the IGF and hedgehog systems. Modulation of stemness in a human normal intestinal epithelial crypt cell line by activation of the WNT signaling pathway. Recombinant Human IL-4 Protein The carrier free version does not contain BSA. Specific activity is for reference purposes only and is not routinely tested. 197: Genetically modified organism Defects in this gene are a cause of insulin-like growth factor I deficiency. Biol. Vaccine Ingredients and Manufacturer Information Search Cytokine and Growth Factor Products, Tissue transglutaminase activates integrin-linked kinase and beta-catenin in ovarian cancer, Generation of a human iPSC line CIBi010-A with a reporter for ASGR1 using CRISPR/Cas9, Targeting Wnt/Tenascin C-Mediated Cross Talk between Pancreatic Cancer Cells and Stellate Cells via activation of the Metastasis Suppressor NDRG1, Coordinate control of basal epithelial cell fate and stem cell maintenance by core EMT transcription factor Zeb1, Elimination of Reprogramming Transgenes Facilitates the Differentiation of Induced Pluripotent Stem Cells into Hepatocyte-like Cells and Hepatic Organoids, Hotspot ESR1 mutations are multimodal and contextual modulators of breast cancer metastasis, Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis, Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-beta/Wnt3a Is Mediated by GLI2 Upregulation, Suspension culture promotes serosal mesothelial development in human intestinal organoids, Combined Systemic Drug Treatment with Proton Therapy: Investigations on Patient-Derived Organoids, Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells, An in vitro stem cell model of human epiblast and yolk sac interaction, Transcriptome-Wide Analysis Reveals a Role for Extracellular Matrix and Integrin Receptor Genes in Otic Neurosensory Differentiation from Human iPSCs, KCTD11 inhibits progression of lung cancer by binding to beta-catenin to regulate the activity of the Wnt and Hippo pathways, Repositioning of duloxetine to target pancreatic stellate cells, The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling, Small molecule allosteric inhibitors of RORgammat block Th17-dependent inflammation and associated gene expression in vivo, Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis, RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy, Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain, Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage, Roles of individual human Dishevelled paralogs in the Wnt signalling pathways, PGC7 promotes tumor oncogenic dedifferentiation through remodeling DNA methylation pattern for key developmental transcription factors, Patient-Specific iPSC-Derived Neural Differentiated and Hepatocyte-like Cells, Carrying the Compound Heterozygous Mutation p.V1023Sfs*15/p.G992R, Present the "Variant" Biochemical Phenotype of Niemann-Pick Type C1 Disease, Deficient LEF1 expression is associated with lithium resistance and hyperexcitability in neurons derived from bipolar disorder patients, Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis, Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell lymphoma by MYH9-mediated regulation of Wnt-beta-catenin-STAT3 signaling, A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies, Generation of human induced pluripotent stem cell lines from 2 patients with MIRAGE syndrome, LGR5/R-Spo1/Wnt3a axis promotes stemness and aggressive phenotype in hepatoblast-like hepatocellular carcinoma cell lines, Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis, 5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer's disease, Triptolide suppresses the growth and metastasis of non-small cell lung cancer by inhibiting &beta-catenin-mediated epithelial-mesenchymal transition, Repression of Wnt/&beta-catenin signaling by SOX9 and Mastermind-like transcriptional coactivator 2, ATF4 promotes lung cancer cell proliferation and invasion partially through regulating Wnt/&beta-catenin signaling, Wnt-&beta-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression, The development of a functional human small intestinal epithelium model for drug absorption, KAT6A, a novel regulator of &beta-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1, Development of selective bispecific Wnt mimetics for bone loss and repair, Ubiquitin-specific protease 53 promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells, Generation of equine enteroids and enteroid-derived 2D monolayers that are responsive to microbial mimics, Chemically Defined Conditions Mediate an Efficient Induction of Dental Pulp Pluripotent-Like Stem Cells into Hepatocyte-Like Cells, Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection, WNT/&beta-catenin-suppressed FTO expression increases m6A of c-Myc mRNA to promote tumor cell glycolysis and tumorigenesis, Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy, Global chromatin organizer SATB1 acts as a context-dependent regulator of the Wnt/Wg target genes, USP28 facilitates pancreatic cancer progression through activation of Wnt/beta-catenin pathway via stabilising FOXM1, Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening, Farnesyl dimethyl chromanol targets colon cancer stem cells and prevents colorectal cancer metastasis, Pluripotent Stem Cell-Derived Hepatocytes Inhibit T Cell Proliferation In Vitro through Tryptophan Starvation, R-Spondin 2 Induces Odontogenic Differentiation of Dental Pulp Stem/Progenitor Cells via Regulation of Wnt/beta-Catenin Signaling, Wnt/&beta-catenin signaling pathway inhibits porcine reproductive and respiratory syndrome virus replication by enhancing the nuclear factor-&kappaB-dependent innate immune response, YAP-TEAD1 control of cytoskeleton dynamics and intracellular tension guides human pluripotent stem cell mesoderm specification, Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids, Generation and characterization of human induced pluripotent stem cells (iPSCs) from hand osteoarthritis patient-derived fibroblasts, Norrin restores blood-retinal barrier properties after vascular endothelial growth factor-induced permeability, Implementing cell-free DNA of pancreatic cancer patient-derived organoids for personalized oncology, The Transcription Factor-microRNA Regulatory Network during hESC-chondrogenesis, SULF1 suppresses Wnt3A-driven growth of bone metastatic prostate cancer in perlecan-modified 3D cancer-stroma-macrophage triculture models, Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State, Induced pluripotent stem cell-derived tenocyte-like cells promote the regeneration of injured tendons in mice, The Microfluidic Environment Reveals a Hidden Role of Self-Organizing Extracellular Matrix in Hepatic Commitment and Organoid Formation of hiPSCs, Aspirin Rescues Wnt-Driven Stem-like Phenotype in Human Intestinal Organoids and Increases the Wnt Antagonist Dickkopf-1, Activation of &beta-catenin by TGF-&beta1 promotes ligament-fibroblastic differentiation and inhibits cementoblastic differentiation of human periodontal ligament cells, Epigenetic regulator function through mouse gastrulation, Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency, Aberrant expression of NKL homeobox genes HMX2 and HMX3 interferes with cell differentiation in acute myeloid leukemia, Notch signalling drives synovial fibroblast identity and arthritis pathology, LSD1 inhibition yields functional insulin-producing cells from human embryonic stem cells, Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription, Identification and validation of the phosphorylation sites on Aristaless-related homeobox protein, Propionate Enhances Cell Speed and Persistence to Promote Intestinal Epithelial Turnover and Repair, Aquaporin 1 promotes sensitivity of anthracycline chemotherapy in breast cancer by inhibiting &beta-catenin degradation to enhance TopoII&alpha activity, Expression of MALAT1 Promotes Trastuzumab Resistance in HER2 Overexpressing Breast Cancers, Fallopian Tube Basal Stem Cells Reproducing the Epithelial Sheets In Vitro-Stem Cell of Fallopian Epithelium, FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits, R-Spondin 2 Induces Odontogenic Differentiation of Dental Pulp Stem/Progenitor Cells via Regulation of Wnt/&beta-Catenin Signaling, PWP1 Promotes the Malignant Phenotypes of Lung Cancer Cells by Interacting with DVL2 and Merlin, Elevated Dkk1 Mediates Downregulation of the Canonical Wnt Pathway and Lysosomal Loss in an iPSC Model of Neuronopathic Gaucher Disease, Understanding the regulatory mechanisms of endometrial cells on activities of endometrial mesenchymal stem-like cells during menstruation, Generation of a human iPSC line CIBi008-A from amniotic fluid-derived cells of a fetus with &beta-thalassemia carrying variants of -28A>G and IVS-II-654C>T in HBB, iPSC-Derived Intestinal Organoids from Cystic Fibrosis Patients Acquire CFTR Activity upon TALEN-Mediated Repair of the p.F508del Mutation, Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma, Generation of intestinal organoids derived from human pluripotent stem cells for drug testing, Familial hypercholesterolemia class II low density lipoprotein-receptor response to statin treatment, Canonical and non-canonical Wnt signaling are simultaneously activated by Wnts in colon cancer cells, A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets, Identification of a Repair-Supportive Mesenchymal Cell Population during Airway Epithelial Regeneration, Development of Physiologically Responsive Human iPSC-Derived Intestinal Epithelium to Study Barrier Dysfunction in IBD, Norrin mediates tumor-promoting and -suppressive effects in glioblastoma via Notch and WNT, Structural insight into small molecule action on Frizzleds, Wnt-3a Induces Epigenetic Remodeling in Human Dental Pulp Stem Cells, Cancer cell-intrinsic function of CD177 in attenuating beta-catenin signaling, Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells, COL4A2 in the tissue-specific extracellular matrix plays important role on osteogenic differentiation of periodontal ligament stem cells, Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure, Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells, Robust, Long-Term Culture of Endoderm-Derived Hepatic Organoids for Disease Modeling, Controlled modelling of human epiblast and amnion development using stem cells, In vitro metabolic zonation through oxygen gradient on a chip, Microenvironmental Factors Drive Tenascin C and Src Cooperation to Promote Invadopodia Formation in Ewing Sarcoma, PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism, Enteroendocrine progenitor cell enriched miR-7 regulates intestinal epithelial proliferation in an Xiap-dependent manner, Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor, Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis, USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification, Enhanced chondrogenesis from human embryonic stem cells, WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis, Horizontal Boundary Cells, a Special Group of Somitic Cells, Play Crucial Roles in the Formation of Dorsoventral Compartments in Teleost Somite, An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos, Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair, Gfi1b regulates the level of Wnt/?-catenin signaling in hematopoietic stem cells and megakaryocytes, Point mutations in the PDX1 transactivation domain impair human ?-cell development and function, Dickkopf-1 (DKK1) promotes tumor growth via Akt-phosphorylation and independently of Wnt-axis in Barrett's associated esophageal adenocarcinoma, In-depth characterization of the Wnt-signaling/?-catenin pathway in an in vitro model of Barrett's sequence, Induction of Expandable Tissue-Specific Progenitor Cells from Human Pancreatic Tissue through Transient Expression of Defined Factors, Excess growth hormone suppresses DNA damage repair in epithelial cells, Wnt Glycation Inhibits Canonical Signaling, Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells, ZNF326 promotes malignant phenotype of glioma by up-regulating HDAC7 expression and activating Wnt pathway, Immunomodulatory effects of interferon-gamma on human fetal cardiac mesenchymal stromal cells, Microenvironmental IL1beta promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling, TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer, Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis, E2A attenuates tumor-initiating capacity of colorectal cancer cells via the Wnt/beta-catenin pathway, Vitamin D and Wnt3A have additive and partially overlapping modulatory effects on gene expression and phenotype in human colon fibroblasts, LGR5 and BMI1 Increase Pig Intestinal Epithelial Cell Proliferation by Stimulating WNT/?-Catenin Signaling, Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors, Cardiotrophic Growth Factor-Driven Induction of Human Muse Cells Into Cardiomyocyte-Like Phenotype, A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family, Expression of the human antimicrobial peptide ?-defensin-1 is repressed by the EGFR-ERK-MYC axis in colonic epithelial cells, Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells, EPH receptor A2 governs a feedback loop that activates Wnt/?-catenin signaling in gastric cancer, Six3 and Six6 Are Jointly Required for the Maintenance of Multipotent Retinal Progenitors through Both Positive and Negative Regulation, Lineage-Specific Chiral Biases of Human Embryonic Stem Cells during Differentiation, A20 regulates canonical wnt-signaling through an interaction with RIPK4, Transcriptome 3'end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma, Expansion of human primary hepatocytes in vitro through their amplification as liver progenitors in a 3D organoid system, Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/?-Catenin Signaling, Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips. Intended for treatment of incomplete and complete chronic traumatic spinal cord injury, Autologous cultured chondrocytes integrated in a scaffold, Intended for repair of symptomatic cartilage defects in joints such as the knee and ankle. Wnt-3a also promotes self-renewal of hematopoietic stem cells, neural stem cells, and embryonic stem cells (13,14). Focal adhesion kinase and Wnt signaling regulate human ductal carcinoma in situ stem cell activity and response to radiotherapy. Lyophilized from a 0.2 m filtered solution in PBS, EDTA and CHAPS. ). (CF). To ensure recovery, reconstitute 2 g vials at 20 g/mL in sterile 4 mM HCl containing 1 mg/mL human or bovine serum albumin. 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